Probiotic RSS

Bacillus subtilis antibiotics: structures, syntheses and specific functions The endospore-forming rhizobacterium Bacillus sub- tilis – the model system for Gram-positive organisms, is able to produce more than two dozen antibiotics with an amazing variety of structures. The produced anti-microbial active compounds include predominantly peptides that are either ribosomally synthesized and post-translationally modified (lantibiotics and lantibiotic-like peptides) or non-ribosomally generated, as well as a couple of non-peptidic compounds such as polyketides, an aminosugar, and a phospholipid. Here I summarize the structures of all known B. subtilis antibiotics, their biochemistry and genetic analysis of their biosynthesis. An updated summary of well-studied antibiotic...

The volume of microbiome research in the past 12 months has been astounding... and we still haven't figured out all there is to know yet.