FLORISH SPORE PROBIOTIC, FULFIXER, Fulvic Acid, Gut Health, Health, Microbiome, Nutrition, Research - November 06, 2025

Detoxing After COVID and the Spike Protein: Functional Strategies for Recovery and Renewal

Understanding the Spike Protein — and Why It Matters for Recovery

When COVID-19 first arrived, few could have predicted the lasting ripple effects it would leave on human health. Beyond the infection itself, we are now learning that the spike protein — the part of the virus that allows it to enter human cells — can sometimes persist in the body, continuing to trigger inflammation and immune responses long after recovery.

While the spike protein has also been used in the design of several vaccines, recent research has opened up important discussions around its potential lingering effects — not only from infection but, in some cases, after vaccination. Functional and integrative medicine practitioners have been at the forefront of studying ways to support the body’s natural detoxification systems to restore balance, reduce inflammation, and rebuild vitality.

At Sebastian Siebert Supplements, we focus on holistic recovery — using research-backed natural compounds, proper nutrition, and cellular support to help the body regain its innate ability to heal.

The Spike Protein: What the Research Now Shows

The SARS-CoV-2 spike protein is a highly active molecule that binds to ACE2 receptors, found in abundance throughout the body — including the lining of the lungs, blood vessels, brain, and gut. This interaction partly explains why COVID-19 can affect so many systems.

Recent studies have shown that in some individuals, fragments of spike protein or viral RNA can persist in tissues or blood for months after the acute infection has resolved. This lingering presence is believed to be one of the contributing factors to what many people experience as “long COVID” — ongoing fatigue, brain fog, cardiovascular issues, and inflammatory symptoms.

There is also increasing recognition that in rare cases, spike protein can circulate in the bloodstream after vaccination, particularly in those who experience prolonged inflammatory symptoms. While this is not common, it supports the need for post-COVID and post-vaccine care protocols that help clear inflammation, restore mitochondrial function, and detoxify safely.

Why the Spike Protein Is Problematic

The spike protein’s role in disease lies in how it interacts with cell membranes and inflammatory pathways:

Inflammation and oxidative stress – Spike protein can activate immune cells and trigger oxidative stress, leading to damage in tissues such as the endothelium (the lining of blood vessels).
Mitochondrial disruption – It may interfere with energy production at a cellular level, reducing ATP output and contributing to fatigue and poor recovery.
Microclot formation – Studies have found microclots and fibrin deposits in people with lingering symptoms, likely due to endothelial activation.
Autoimmune-like reactions – In sensitive individuals, prolonged exposure to spike protein may confuse immune tolerance, creating inflammation similar to autoimmune responses.

The body’s detoxification systems — the liver, kidneys, lymph, and microbiome — naturally work to clear such challenges, but in cases of heavy immune load or poor nutrient status, these systems can become overwhelmed.

That’s where targeted functional support becomes essential.

The Functional Medicine Approach to Spike Protein Detox

Functional medicine does not rely on “quick fixes” or one-size-fits-all detoxes. Instead, it focuses on restoring the body’s own regulatory systems: mitochondrial function, antioxidant defences, cellular repair, and gut integrity.

Below are the most researched and physiologically grounded approaches to recovering from spike protein exposure or post-COVID inflammation.

1. Support Antioxidant Defence: Glutathione and NAC

One of the most powerful tools against spike-related oxidative stress is the amino acid N-acetylcysteine (NAC), which is a direct precursor to glutathione, the body’s master antioxidant.

Research has shown that NAC can help:

Reduce inflammatory cytokines
Improve oxygen utilisation
Support liver detoxification
Break down mucus and biofilms in the respiratory tract

Clinical studies have also demonstrated NAC’s ability to reduce the severity of viral infections and support recovery in long-COVID cases.

For those recovering post-COVID or post-vaccination, supplementing with NAC under professional supervision can assist the liver in neutralising reactive oxygen species and restoring redox balance.

2. Rebuild the Gut–Immune Axis

The gut microbiome is one of the most crucial regulators of systemic inflammation and immune balance. The spike protein can disrupt the gut lining by binding to ACE2 receptors in the intestinal wall, leading to increased permeability (“leaky gut”) and microbial imbalance.

This is where a spore-based probiotic such as FLORISH Spore Probiotic with Fulvic Acid becomes an essential part of the recovery toolkit.

Spore probiotics have a unique ability to survive stomach acid and colonise the gut effectively. Research has shown that these hardy bacterial strains can:

Rebuild the gut barrier and restore tight junction integrity
Reduce systemic inflammation and cytokine activity
Stimulate short-chain fatty acid production for gut healing
Support detoxification pathways through better liver–gut communication

The addition of Fulvic Acid in FLORISH enhances the transport and absorption of nutrients and assists in binding and removing residual toxins from the system, helping to restore mineral balance and cellular energy.

3. Restore Mitochondrial Function

Many long-COVID patients report fatigue, brain fog, and muscle weakness — classic signs of mitochondrial dysfunction. The mitochondria are the powerhouses of the cell, and the spike protein’s interference with their function can cause oxidative damage and decreased ATP output.

Nutrients that help restore mitochondrial energy include:

Coenzyme Q10 – essential for energy production in cardiac and muscle tissue
Alpha-lipoic acid – a potent antioxidant that regenerates glutathione
Fulvic Acid – shown to enhance mitochondrial membrane potential and improve the transport of key electrolytes and trace minerals
Magnesium and B-vitamins – co-factors for mitochondrial enzymes

Combining FULFIXER Fulvic Acid with mitochondrial support nutrients provides a synergistic effect — promoting cellular detoxification while replenishing trace minerals lost through stress and inflammation.

4. Reduce Inflammation Naturally

Inflammation is the body’s response to injury — but chronic inflammation is what causes damage over time. To calm this, functional medicine favours natural modulators rather than pharmaceuticals wherever possible.

Effective anti-inflammatory nutrients include:

Curcumin – clinically shown to inhibit NF-κB pathways
Omega-3 fatty acids (EPA/DHA) – reduce inflammatory cytokines
Resveratrol and quercetin – support endothelial health and reduce viral binding activity
Vitamin D3 – essential for immune regulation and reduction of inflammatory markers

Research also indicates that maintaining sufficient vitamin D status is crucial for reducing the severity of both acute and long-term post-viral symptoms.

5. Support Circulation and Microclot Resolution

Microclots have been found in some long-COVID patients and may explain symptoms such as poor circulation, breathlessness, and brain fog. To support microvascular health:

Nattokinase, a fibrinolytic enzyme derived from fermented soy, has shown promise in helping dissolve microclots and improving blood flow.
Bromelain, from pineapple, has natural anti-inflammatory and antithrombotic properties.
Fulvic Acid further assists by improving red blood cell membrane function and oxygen delivery.

Together, these compounds may support the restoration of healthy microcirculation and oxygenation at the tissue level — a critical step in full recovery.

6. Detoxification Pathways and Cellular Cleansing

The liver is the central organ responsible for neutralising and clearing metabolic waste, including inflammatory debris. To function efficiently, it requires optimal nutrition and antioxidant capacity.

Key liver-supportive nutrients include:

Milk Thistle (Silymarin) – enhances glutathione synthesis and protects hepatocytes
Dandelion root – improves bile flow and digestion
Sulforaphane (from broccoli sprouts) – activates Phase II liver detox enzymes

Combining these with FULFIXER Fulvic Acid capsules can amplify detoxification by providing trace minerals and improving the transport of nutrients into cells while removing unwanted residues out of them.

7. Hydration, Electrolytes, and Trace Minerals

Post-viral recovery often leaves the body depleted of essential minerals such as zinc, selenium, and magnesium — all critical for immune and mitochondrial function.

Fulvic Acid serves as a natural electrolyte transporter, helping the body restore mineral balance more effectively than standard supplementation alone. It assists in binding free radicals, improving hydration, and ensuring that nutrients reach the cellular interior where they are needed most.

Adequate hydration — with mineral-rich spring or filtered water — is vital for lymphatic drainage and metabolic detox.

The FLORISH + FULFIXER Protocol for Spike Protein Recovery

At Sebastian Siebert Supplements, we recommend a simple yet powerful foundation for restoring balance and resilience after spike-related inflammation:

Morning – Take 2 capsules of FULFIXER Fulvic Acid with a large glass of water to activate mineral transport and cellular detoxification.
Breakfast – Include whole proteins, omega-3-rich fats, and low-glycaemic fruits to support antioxidant capacity.
Midday – Take 1 capsule of FLORISH Spore Probiotic with Fulvic Acid with or after lunch to rebuild the gut–immune axis.
Evening – Hydrate, rest, and prioritise sleep; consider magnesium supplementation to calm the nervous system and support mitochondrial repair.

This synergistic pairing helps to:

Rebuild gut integrity and reduce systemic inflammation
Enhance nutrient uptake and detoxification
Support mitochondrial function and cellular regeneration
Promote the body’s natural antioxidant and immune systems

These are not pharmaceuticals — they are cellular allies that work with your body, not against it.

Long-Term Wellness After Spike Protein Exposure

Healing from spike protein-related effects — whether after infection or vaccination — requires time, patience, and consistency. The goal is not simply to “flush out” the protein, but to rebalance the entire system so the body can process and eliminate what it no longer needs.

When you nourish your gut, restore your minerals, and support mitochondrial function, you empower your body’s innate intelligence to recover fully.

In Summary

The spike protein can persist in some individuals and may contribute to lingering post-COVID symptoms.
Functional medicine offers a science-guided, holistic approach to recovery — supporting detoxification, mitochondria, and the microbiome.
Supplements like FLORISH Spore Probiotic with Fulvic Acid and FULFIXER Fulvic Acid can help optimise nutrient absorption, balance the gut, and support cellular detoxification.
True recovery requires not just symptom management but system restoration — helping every cell return to balance and vitality.

At Sebastian Siebert Supplements, our mission is to provide the highest quality, clinically informed supplements that help the body do what it was designed to do: heal itself.

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